![]() Hydroxocobalamin differs from these antidotes in that it has not been associated with clinically significant toxicity in antidotal doses. The potential for serious toxicity limits or prevents the use of the Cyanide Antidote Kit, dicobalt edetate, and 4-dimethylaminophenol in prehospital empiric treatment of suspected cyanide poisoning. The data available to date do not suggest obvious differences in efficacy among antidotes, with the exception of a slower onset of action of sodium thiosulfate (administered alone) than of the other antidotes. Each of the antidotes shows evidence of efficacy in animal studies and clinical experience. This paper reviews preclinical and clinical data on available cyanide antidotes and considers the profiles of these antidotes relative to properties of a hypothetical ideal cyanide antidote. Critical assessment of cyanide antidotes is needed to aid in therapeutic and administrative decisions that will improve care for victims of cyanide poisoning (particularly poisoning from enclosed-space fire-smoke inhalation), and enhance readiness for cyanide toxic terrorism and other mass-casualty incidents. The international medical community lacks consensus about the antidote or antidotes with the best risk-benefit ratio. Make sure any doctor caring for your pregnancy or your baby knows you have received this medication.Cyanide has several antidotes, with differing mechanisms of action and diverse toxicological, clinical, and risk-benefit profiles. In an emergency situation, it may not be possible before you are treated with hydroxocobalamin to tell your caregivers if you are pregnant or breast feeding. You should not breast-feed after you have been treated with hydroxocobalamin. It is not known whether hydroxocobalamin passes into breast milk or if it could harm a nursing baby. ![]() However, the benefits of treating cyanide poisoning may outweigh any risks posed by hydroxocobalamin, for both you and your baby. It is not known whether hydroxocobalamin will harm an unborn baby. If you have ever had a severe allergic reaction to hydroxocobalamin, Vitamin B12, or cyanocobalamin ( Nascobal, Cobolin, Cyomin, and others).įDA pregnancy category C. ![]() Kidney disease (or if you are on dialysis) or If possible before you receive hydroxocobalamin, tell your caregivers if you have: You may report side effects to FDA at 1-80. Call your doctor for medical advice about side effects. This is not a complete list of side effects and others may occur. Pain, swelling, or irritation of your skin where the injection was given. Red coloring of your urine (may last 2 to 5 weeks) or Severe shortness of breath, wheezing, gasping for breath, cough with foamy mucus Ī light-headed feeling, like you might pass out orĭangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).Ĭommon side effects of Hydroxocobalamin may include: Call your doctor if you have a rash that lasts longer than 4 weeks.Ĭall your doctor at once if you have a serious side effect such as: This rash should go away without treatment. ![]() You may develop an acne-like skin rash within 1 to 4 weeks after you are treated with hydroxocobalamin. Get emergency medical help if you have any of these signs of an allergic reaction: hives chest tightness, difficulty breathing swelling of your face, lips, tongue, or throat.
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